Tumor burden involving the spleen or bone marrow.6 Possible mechanisms for cancer-associated thrombocytopenia With neoplasia.4 Dogs with lymphoma have the 2nd highestĮstimated risk of developing thrombocytopenia w hen compared to dogs with a variety of other tumors.5 Thrombocytopenia occurs most commonly in patients with extensive Is the most commonly recognized platelet defect in dogs Neoplasia in animals is well established. The association between quantitative platelet defects and Hemostatic profile despite having no clinical evidence of a Eighty-three of 100 dogs withĪ variety of neoplasms had 1 or more abnormality on a Vein thrombosis.3 In many cancer patients, hemostatic abnormalities are subclinical. Thromboembolism2 and in 3 of 11 dogs (27%) with portal Underlying neoplasia was associated with thrombotic disease in 14 of 47 dogs (30%) with pulmonary (DIC).1 All 41 dogs had clinical evidence of abnormalīleeding. Malignant neoplasia was identified in 16 of 41ĭogs (39%) with disseminated intravascular coagulation

Modification of platelet function in patients with lymphoma affects disease progression or outcome.Įmostatic disorders, ranging from hemorrhagic diathesis to thrombosis, occur as complications of neoplasia in dogs. Further investigation is needed to determine if Platelet hyperactivity may play a role in the development of hemostaticĭisorders (eg, disseminated intravascular coagulation) or in tumor metastasis. That platelets from dogs with lymphoma are hyperactive. Platelets from affected dogs had significantly greater maximum aggregation than those from control dogs, suggesting Platelet disorders (ie, thrombocytopenia or thrombocytosis) or with clinical evidence of a bleeding disorder were excluded from Lymphoma and 10 normal control dogs to determine if dogs with lymphoma have altered platelet function. Whole-blood platelet aggregation and adenosine triphosphate secretion were measured in 15 dogs with untreated multicentric

Platelet Aggregation and Adenosine Triphosphate Secretion in Dogs

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